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Alternatives Database InterNICHE

8797

237490.pdf - Chalmers Publication Library

n. 1. a. A line that deviates from straightness in a smooth, continuous fashion.

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Toxicology AUC can be used as a measure of drug exposure. 1978-2-1 There was a significant correlation between level of CYP2E1 mRNA in mononuclear cells and the area under the plasma concentration-time curve of plasma inorganic fluoride from the beginning of sevoflurane administration to infinity in uninduced and uninhibited patients (r2 = 0.56; P < 0.01). 2007-6-17 · Vd = amount of drug/concentration of drug in plasma Vd = dose Cp AUC: the area under the plasma or blood-concentration:time curve. Bioavailability: F = AUC (oral) AUC (IV) MEC: usually a minimum effective concentration (i.e., MTC minimum therapeutic concentration) of drug in the blood or plasma is needed for a therapeutic effect. Clearance: A. Phar­ma­C­alc v02 is an edu­ca­tional tool that al­lows to sim­u­late plasma-​concentration time curves based on chosen phar­ma­cokin­etic para­met­ers. It should help to bet­ter un­der­stand the in­flu­ence of the phar­ma­cokin­etic para­met­ers on plasma-​concentration time curves 2002-10-1 Plasma concentrations, the 17-item Hamilton Depression Rating (HAMD), and the UKU side effect rating were performed weekly.

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Whenever the determination of AUC is partial (incomplete), the time period over which it is determined should be specified, for example, AUC 0–12 h refers to area under the curve from time 0 to 12 h after drug administration AUC - Area Under Plasma Concentration Curves. Looking for abbreviations of AUC? It is Area Under Plasma Concentration Curves.

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Plasma concentration curve

time   Represent graphically the typical natural log of plasma drug concentration versus time curve for a one-compartment model after an intravenous dose. Page 2. 2. Area under the plasma concentration-time curve from time zero to time t.

This is attributed to distribution of the administered drug between the central compartment and tissue (peripheral compartment). In (plasma concentration time curve) In (Plasma concentration). time curve -2.5 -4.0 -4.5 125 150 175 200 225 250 275 300 325 Time (h) In(Plasma concentration C (mg/L)) min) max) plasma concentration time curve Plasma concentration -time curve 300 325 0.200 0.175 0.150 0.125 0.100 0.075 0.050 0.025 125 Plasma concentration C (mg/L) 150 175 200 225 1.
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In (plasma concentration time curve) In (Plasma concentration). time curve -2.5 -4.0 -4.5 125 150 175 200 225 250 275 300 325 Time (h) In(Plasma concentration C (mg/L)) min) max) plasma concentration time curve Plasma concentration -time curve 300 325 0.200 0.175 0.150 0.125 0.100 0.075 0.050 0.025 125 Plasma concentration C (mg/L) 150 175 200 225 1. A nonangular continuous bend or line.

One reason to use plasma concentration is to test levels of compounds found naturally in the body, like C reactive protein, which … centration of drug in plasma increases, the concentration of drug in most tissues will increase proportionally. Similarly, if the plasma concentration of a drug is decreasing, the concentration in tissues will also decrease. Figure 1-3 is a simplified plot of the drug con-centration versus time profile after an intravenous drug 1998-4-1 The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin. Switching from inhibition to induction of cytochrome P450 3A (CYP3A) enzymes causes a very great (400-fold) change in the AUC of oral midazolam.
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Although the  Membrane potentials in cells are determined primarily by three factors: 1) the concentration of ions on the inside and outside of the cell; 2) the permeability of the  1 May 2008 Question: How is renal plasma flow (RPF) measured? Answer: By measuring para-aminohippurate (PAH) clearance. How does it work?


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Assistant Functions SHIMADZU SWEDEN

Time Curve. If you look at the following curve, you see a rapid increase marked "absorption phase", and a gradual decrease marked "elimination phase". This is the amount of a particular medication in the blood, which quickly increases after the medication is administered, reaching a peak some time after The plasma drug concentration above the MEC is called area under the curve (AUC).

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“Integral of the plasma drug concentration-time curve” Description. The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug Clinical implications.

1. a. A line that deviates from straightness in a smooth, continuous fashion. b. Purpose: The target area under the plasma-concentration-versus-time curve (AUC)-based dosing of carboplatin using Calvert's formula is expected to result in more acceptable toxicity and greater efficacy in elderly patients with small-cell lung cancer (SCLC) than the body surface area-based dosing strategy.