Osteoadherin

U Petersson, K Hultenby, M Wendel. European journal of oral sciences 111 (2), Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate.

ELISA detected osteoadherin in bovine bone only, and immunohistochemical analysis of bovine fetal rib growth plate showed osteoadherin exclusively in primary bone spongiosa. A: Chelating agents such as EDTA, Heparin and Citrate can bind metal ions from the functional domain of Osteoadherin causing degradation of its protein structure. Osteoadherin may be denatured as a result and may compromise the assay's measurements. Our Osteoadherin/OSAD/OMD Antibodies can be used in a variety of model species: Human, Mouse. Use the list below to choose the Osteoadherin/OSAD/OMD Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and … 1998-05-01 There are currently no images for Osteoadherin/OSAD/OMD Antibody (NBP2-89674).

Bovine osteoadherin contains leucine-rich repeats (LRRs) and is also rich in aspartic acid and glutamic acid. It had an apparent molecular mass of 85 kD under reducing conditions by SDS-PAGE. ELISA detected osteoadherin in bovine bone only, and immunohistochemical analysis of bovine fetal rib growth plate showed osteoadherin exclusively in primary bone spongiosa.

Due to OSAD's capacity to bind hydroxyapatite crystals, a role for the protein in the mineralization process has also been suggested. Osteoadherin is a recently described bone proteogly-can containing keratan sulfate. It promotes integrin (a vb 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847).

Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet and one alpha-helix. 27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons. It is a member of the Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily. This protein is reported to have a secreted cellular Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3).
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800-343-7475; Contact Us; Cart Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin.

It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP).
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Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3). 116847 Ensembl ENSG00000188783 ENSMUSG00000041577 UniProt P51888 Q9JK53 RefSeq (mRNA) NM_201348 NM_002725 NM_054077 RefSeq (protein) NP_002716 NP_958505 NP_473418 Location (UCSC) Chr 1: 203.48 – 203.49 Mb Chr 1: 133.91 – 133.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Prolargin is a protein that in humans is encoded by the PRELP gene. The protein encoded by this gene is a Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h) 2017-02-28 · Osteoadherin (OSAD) is a bone proteoglycan containing keratan sulfate that belongs to the small leucine-rich proteoglycan (SLRP) family.

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This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids.

J. Cell Jan 28, 2020 The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding The regulation of osteoadherin by neurotrophins in both osteoblasts and dental pulp cells suggests that a complex signaling network occurs during the NP_005005.1 osteomodulin 229 OMD_HUMAN Osteomodulin precursor ( Osteoadherin) (OSAD) (Keratan sulfate. Q99983 proteoglycan osteomodulin) ( KSPG Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown.

Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. 1998-07-03 · Osteoadherin, a Cell-binding Keratan Sulfate Proteoglycan in Bone, Belongs to the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix. *. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3 )-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues.